NSAID Antiinflammatory Antipyretic Analgesics

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Alphabetical

Preparations

  1. Aspirin:
    Antiinflammatory dose 3–5 g/day (75–100 mg/kg/day)
    analgesic-antipyretic dose 0.3–0.6 g 6–8 hourly
    antiplatelet dose 75–150 mg/day. ASPIRIN 350 mg tab, COLSPRIN 100, 325 mg tabs, ECOSPRIN 75, 150, 325 mg tabs, DISPRIN 325 mg (with calcium carbonate 105 mg + citric acid 35 mg) tab, LOPRIN 75, 162.5 mg tabs. BIOSPIRIN: Lysine acetylsalicylate 900 mg + glycine 100 mg/vial for dissolving in 5 ml water and i.v. injection.
  2. Indomethacin:
    25–50 mg BD–QID. Those not tolerating the drug orally may be given nightly suppository.
    IDICIN, INDOCAP 25 mg cap, 75 mg SR cap, ARTICID 25, 50 mg cap, INDOFLAM 25, 75 mg caps, 1% eye drop. RECTICIN 50 mg suppository.
  3. Ibuprofen:
    400–800 mg TDS
    BRUFEN, EMFLAM, IBUSYNTH 200, 400, 600 mg tab, IBUGESIC also 100 mg/5 ml susp.
  4. Naproxen:
    250 mg BD–TDS
    NAPROSYN, NAXID, ARTAGEN, XENOBID 250 mg tab, NAPROSYN also 500 mg tab.
  5. Ketoprofen:
    50–100 mg BD–TDS
    KETOFEN 50, 100 mg tab; OSTOFEN 50 mg cap. RHOFENID 100 mg tab, 200 mg SR tab; 100 mg/2 ml amp.
  6. Flurbiprofen:
    50 mg BD–QID
    ARFLUR 50, 100 mg tab, 200 mg SR tab, FLUROFEN 100 mg tab, OCUFLUR 0.03% eye drops.
  7. Mephenamic acid:
    250–500 mg TDS
    MEDOL 250, 500 mg cap; MEFTAL 250, 500 mg tab, 100 mg/5 ml susp. PONSTAN 125, 250, 500 mg tab, 50 mg/ml syrup.
  8. Diclofenac:
    50 mg TDS, then BD oral, 75 mg deep i.m.
    VOVERAN, DICLONAC, MOVONAC 50 mg enteric coated tab, 100 mg S.R. tab, 25 mg/ml in 3 ml amp. for i.m. inj. DICLOMAX 25, 50 mg tab, 75 mg/3 ml inj. Diclofenac potassium: VOLTAFLAM 25, 50 mg tab, ULTRA-K 50 mg tab; VOVERAN 1% topical gel.
  9. Aceclofenac:
    100 mg BD
    ACECLO, DOLOKIND 100 mg tab, 200 mg SR tab. 25 Nonsteroidal Antiinflammatory Drugs/ Antipyretic-Analgesics
  10. Piroxicam:
    20 mg BD for two days followed by 20 mg OD
    DOLONEX, PIROX 10, 20 mg cap, 20 mg dispersible tab, 20 mg/ml inj in 1 and 2 ml amps; PIRICAM 10, 20 mg cap.
  11. Tenoxicam:
    20 mg OD
    TOBITIL 20 mg tab.
  12. Ketorolac:
    10–20 mg oral 6 hourly, 15–30 mg i.m./i.v. 6 hourly (max 90 mg/day)
    KETOROL, ZOROVON, KETANOV, TOROLAC 10 mg tab, 30 mg in 1 ml amp., KETLUR, ACULAR 0.5% eye drops.
  13. Nimesulide:
    100 mg BD
    NIMULID, NIMEGESIC, NIMODOL 100 mg tab, 50 mg/5 ml susp.
  14. Meloxicam:
    7.5–15 mg OD
    MELFLAM, MEL–OD, MUVIK, M–CAM 7.5 mg, 15 mg tabs.
  15. Nabumetone:
    500 mg OD
    NABUFLAM 500 mg tab.
  16. Etodolac:
    200-400 mg BD-TDS
    ETOVA 200, 300, 400 mg tabs.
  17. Celecoxib:
    100–200 mg BD
    CELACT, CELCOX, COLCIBRA, COBIX 100, 200 mg tabs.
  18. Etoricoxib:
    60–120 mg OD
    TOROCOXIA, ETOXIB, ETOSHINE, NUCOXIA 60, 90, 120 mg tabs.
  19. Parecoxib:
    40 mg oral/i.m./i.v. repeated after 6–12 hours (max. 80 mg/day)
    PAROXIB 40 mg tab, REVALDO, VALTO-P 40 mg/vial inj.
  20. Paracetamol:
    325–650 mg (children 10–15 mg/kg) 3-5 times a day (max. 2600 mg/day); also 80–250 mg as suppository in infants and children;
    CROCIN 0.5 g tab, 125 mg/5 ml and 250 mg/5 ml syr, 100 mg/ml pediatric drops, CROCIN PAIN RELIEF 650 mg with caffeine 50 mg tab; METACIN, PARACIN 500 mg tab, 125 mg/5 ml syrup, 150 mg/ml ped. drops, ULTRAGIN, PYRIGESIC, CALPOL 500 mg tab, 125 mg/5 ml syrup, NEOMOL, FEVASTIN, FEBRINIL 300 mg/2 ml inj. JUNIMOL-RDS 80, 170, 250 mg suppository, PARACETAMOL RECTAL SUPPOSITORY 80, 170 mg.
  21. Metamizol:
    0.5–1.5 g oral/i.m./i.v.
    ANALGIN 0.5 g tab; NOVALGIN, BARALGAN 0.5 g tab, 0.5 g/ml in 2 ml and 5 ml amps; ULTRAGIN 0.5 g/ml inj in 2 ml amp and 30 ml vial. Autacoids and Related Drugs 26
  22. Propiphenazone:
    300–600 mg TDS
    marketed only in combi nation in several ‘over the counter’ preparations–in SARIDON, ANAFEBRIN:
    propiphenazone 150 mg + paracetamol 250 mg tab, DART:
    propiphenazone 150 mg + paracetamol 300 mg + caffeine 50 mg tab.
  23. Nefopam:
    30–60 mg TDS oral, 20 mg i.m. 6 hourly
    NEFOMAX 30 mg tab, 20 mg in 1 ml amp.

Topical NSAIDs

  1. Diclofenac 1% gel:
    VOLINI GEL, RELAXYL GEL, DICLONAC GEL
  2. Ibuprofen 10% gel:
    RIBUFEN GEL
  3. Naproxen 10% gel:
    NAPROSYN GEL
  4. Ketoprofen 2.5% gel:
    RHOFENID GEL
  5. Flurbiprofen 5% gel:
    FROBEN GEL
  6. Nimesulide 1% gel:
    NIMULID TRANS GEL, ZOLANDIN GEL, NIMEGESIC-T-GEL
  7. Piroxicam 0.5% gel:
    DOLONEX GEL, MOVON GEL, PIROX GEL, MINICAM GEL

Classification

A. Nonselective COX inhibitors (conventional NSAIDs)

  1. Salicylates: Aspirin.
  2. Propionic acid derivatives: Ibuprofen, Naproxen, Ketoprofen, Flurbiprofen.
  3. Anthranilic acid derivative: Mephenamic acid.
  4. Aryl-acetic acid derivatives: Diclofenac, Aceclofenac.
  5. Oxicam derivatives: Piroxicam, Tenoxicam.
  6. Pyrrolo-pyrrole derivative: Ketorolac.
  7. Indole derivative: Indomethacin.
  8. Pyrazolone derivatives: Phenylbutazone, Oxyphen-butazone.

B. Preferential COX-2 inhibitors
Nimesulide, Meloxicam, Nabumetone, Etodolac.

C. Selective COX-2 inhibitors
Celecoxib, Etoricoxib, Parecoxib.

D. Analgesic-antipyretics with poor antiinflammatory action

  1. Paraaminophenol derivative: Paracetamol (Aceta-minophen).
  2. Pyrazolone derivatives: Metamizol (Dipyrone), Propiphenazone.
  3. Benzoxazocine derivative: Nefopam.